AbstractAnti‐Black racism including structural racism and racism‐related disparities have come to the foreground in recent years with the increasingly frequent and brutal police killings of innocent African Americans, the disproportionate impacts of the pandemic on the Black community, and the effectiveness of the Black Lives Matter movement. There have been calls to action to ensure cultural effectiveness of couples and family therapy for African Americans. As one response to these calls, this article provides recommendations for culturally humble and anti‐racist couple and family interventions. These best practices focus on the necessity of embracing a systemic stance and a strengths‐based culturally responsive lens when assessing and intervening with African American couples and families. They focus on the need for therapists to be intentional about and consistent in engaging in self‐exploration and taking the necessary steps to be not just competent but also capable. The final set of best practices detailed relate to assessing and intervening using a strengths‐based approach in a culturally responsive, anti‐racist, and socially attuned fashion. The article concludes with recommendations for couple/family therapists to develop a critical consciousness, engage in anti‐racist practices, and address oppression while advancing healing and liberation, all of which are essential to ensuring the resilience and well‐being of African American couples and families.