Published in

Springer Nature [academic journals on], Molecular Psychiatry, 11(27), p. 4419-4431, 2022

DOI: 10.1038/s41380-022-01710-8



Export citation

Search in Google Scholar

Genome-wide meta-analyses reveal novel loci for verbal short-term memory and learning

Journal article published in 2022 by Jari Lahti ORCID, Samuli Tuominen ORCID, Qiong Yang ORCID, Giulio Pergola ORCID, Shahzad Ahmad ORCID, Najaf Amin, Nicola J. Armstrong, Alexa Beiser, Katharina Bey, Joshua C. Bis ORCID, Eric Boerwinkle, Jan Bressler ORCID, Archie Campbell ORCID, Harry Campbell, Qiang Chen and other authors.
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

Full text: Unavailable

Green circle
Preprint: archiving allowed
Orange circle
Postprint: archiving restricted
Red circle
Published version: archiving forbidden
Data provided by SHERPA/RoMEO


Abstract Understanding the genomic basis of memory processes may help in combating neurodegenerative disorders. Hence, we examined the associations of common genetic variants with verbal short-term memory and verbal learning in adults without dementia or stroke (N = 53,637). We identified novel loci in the intronic region of CDH18, and at 13q21 and 3p21.1, as well as an expected signal in the APOE/APOC1/TOMM40 region. These results replicated in an independent sample. Functional and bioinformatic analyses supported many of these loci and further implicated POC1. We showed that polygenic score for verbal learning associated with brain activation in right parieto-occipital region during working memory task. Finally, we showed genetic correlations of these memory traits with several neurocognitive and health outcomes. Our findings suggest a role of several genomic loci in verbal memory processes.