ABSTRACT This study showed the consequences of the new Coronavirus in the working environment and its effects on workers’ health. SARS-CoV-2 has a high transmission level through exhaled droplets, affecting organs such as the lungs, heart, liver, kidneys, and brain. Productive and social activities were interrupted, but many continued to operate due to market pressure. Health professionals are among the most exposed, but activities requiring many people in the same environment are at substantial risk of exposure to Coronavirus. Work can favor and accelerate the destruction caused by the virus. Inadequate economic and social policies contributed to the deterioration of the health crisis, increasing the economic and social crisis, marked by the loss of jobs and increased work instability. Control and prevention measures are required to reduce risk, but they should consider the nature of relationships in the work and social environment. Social isolation, hand hygiene, and masks are recommended measures, besides Personal Protective Equipment and collective measures for workers. The impact of the pandemic marks every worker involved. Several stressors arise or deteriorate, psychologically affecting many employees. Returning to work with adequate planning requires safety to minimize risks and protect workers.