AbstractBackgroundPeyronie's disease (PD) is a fibrosing disorder of the penis resulting in plaque formation and penile deformity that negatively affect sexual and psychosocial function of patients. A multifactorial etiology of PD is assumed with diabetes mellitus (DM) being a potential risk factor.ObjectivesThe aim of this narrative review was to investigate diabetes role in PD pathophysiology, diagnosis, and treatment.Materials and methodsA non‐systematic narrative review of original articles, meta‐analyses, and randomized trials was conducted, including articles in the pre‐clinical setting to support relevant findings.ResultsDiabetes is one of the most common comorbidity observed in PD patients, with a prevalence of about 11% and a strong association with erectile dysfunction (ED). DM is associated with both a higher risk of developing PD and has also an impact on the outcomes of PD's treatments.DiscussionEvidence from literature underlines that metabolic alterations typical of DM are pivotal factors in the development of PD and resistance to its medical treatment.ConclusionThe role of DM in development of PD is still debated, while its role in PD development is not completely clear, there is a clear impact of DM on PD treatment outcomes.