Published in
American Society for Microbiology, Microbiology Spectrum, 3(11), 2023
DOI: 10.1128/spectrum.00380-23
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Identification and Characterization of a New Regulator, TagR, for Environmental Stress Resistance Based on the DNA Methylome of Streptomyces roseosporus
Journal article published in 2023 by
Wen-Li Gao,
Jiao-Le Fang,
Chen-Yang Zhu,
Wei-Feng Xu,
Zhong-Yuan Lyu,
Xin-Ai Chan,
Qing-Wei Zhao,
Yong-Quan Li 
This paper is made freely available by the publisher.
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Abstract
This study established a novel strategy for screening regulators of environmental stress resistance based on the DNA methylome and discovered a new regulator, TagR. The TagR-WTA transporter regulatory pathway improved the resistance and antibiotic yield of strains and has the potential for wide application. Our research provides a new perspective on the optimization and reconstruction of industrial actinomycetes.