Published in
American Association for the Advancement of Science, Science Advances, 36(7), 2021
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The anti-fibrotic drug pirfenidone inhibits liver fibrosis by targeting the small oxidoreductase glutaredoxin-1
Journal article published in 2021 by
Yue Xi 
,
Yanping Li ,
Pengfei Xu ,
Sihan Li,
Zhengsheng Liu,
Hung-Chun Tung ,
Xinran Cai ,
Jingyuan Wang ,
Haozhe Huang,
Menglin Wang ,
Meishu Xu,
Songrong Ren ,
Song Li ,
Min Zhang ,
Yong J. Lee
and other authors.
,
Yanping Li ,
Pengfei Xu ,
Sihan Li,
Zhengsheng Liu,
Hung-Chun Tung ,
Xinran Cai ,
Jingyuan Wang ,
Haozhe Huang,
Menglin Wang ,
Meishu Xu,
Songrong Ren ,
Song Li ,
Min Zhang ,
Yong J. Lee
and other authors.
This paper is made freely available by the publisher.
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Abstract
Pirfenidone inhibits HSC activation and liver fibrosis by targeting glutaredoxin-1 and reducing Smad3 glutathionylation.