Published in
American Association for the Advancement of Science, Science Immunology, 88(8), 2023
DOI: 10.1126/sciimmunol.adj6724
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BCL6 fine-tunes long-term tumor control
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Abstract
Sun et al. provide comprehensive evidence that the transcription factor BCL6 functions as a gatekeeper for CD8 + progenitor cell function in tumors and prevents their excessive terminal differentiation, thereby preserving this stem-like population for long-term tumor control.