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American Physiological Society, AJP - Endocrinology and Metabolism, 5(325), p. E466-E479, 2023

DOI: 10.1152/ajpendo.00093.2023

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Both moderate- and high-intensity exercise training increase intramyocellular lipid droplet abundance and modify myocellular distribution in adults with obesity

Journal article published in 2023 by Michael W. Schleh ORCID, Cheehoon Ahn ORCID, Benjamin J. Ryan ORCID, Olivia K. Chugh, Austin T. Luker, Kathryn E. Luker, Jenna B. Gillen ORCID, Alison C. Ludzki ORCID, Douglas W. Van Pelt ORCID, Lisa M. Pitchford, Tao Zhang, Thomas Rode, Suzette M. Howton, Charles F. Burant, Jeffrey F. Horowitz ORCID
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

In this study, 12 wk of either moderate-intensity continuous training (MICT) or high-intensity interval training (HIIT) enhanced skeletal muscle lipid abundance by increasing lipid droplet number within the intramyofibrillar (IMF) region of muscle. Because the IMF associates with high energy production during muscle contraction, this adaptation may enhance lipid oxidation during exercise. Despite differences in training intensity and energy expenditure between MICT and HIIT, their effects on muscle lipid abundance and metabolism were remarkably similar.