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American Physiological Society, American Journal of Physiology - Lung Cellular and Molecular Physiology, 4(325), p. L460-L466, 2023

DOI: 10.1152/ajplung.00141.2023

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FAM13A regulates cellular senescence marker p21 and mitochondrial reactive oxygen species production in airway epithelial cells

Journal article published in 2023 by Qing Chen ORCID, Gwenda F. Vasse ORCID, Kingsley Okechukwu Nwozor, Nicolaas J. Bekker ORCID, Maarten van den Berge ORCID, Corry-Anke Brandsma ORCID, Maaike de Vries ORCID, Irene H. Heijink ORCID
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

To our knowledge, this is the first study investigating the role of the COPD susceptibility gene FAM13A in aging and cellular senescence. We found that FAM13A negatively regulates the expression of the cellular senescence marker P21 and mitochondrial ROS production in the airway epithelium. In this way, the lower expression of FAM13A observed upon aging may facilitate cellular senescence and potentially contribute to accelerated lung aging in COPD.