American Physiological Society, American Journal of Physiology: Cell Physiology, 4(325), p. C1119-C1130, 2023
DOI: 10.1152/ajpcell.00280.2023
Full text: Unavailable
Alpha-ketoglutaric acid (α-KG) exerted its protective effect on nucleus pulposus cells’ (NPCs) degeneration by inhibiting the senescence-associated secretory phenotype and extracellular matrix degradation. The possible mechanism may be associated with negatively regulating the JAK2/STAT3 phosphorylation and the decreased IL-6 expression, which could be explained by a blockage of the positive feedback control loop between IL-6 and JAK2/STAT3 pathway.