Published in
American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 1(66), 2022
DOI: 10.1128/aac.01652-21
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Impact of FKS1 Genotype on Echinocandin In Vitro Susceptibility in Candida auris and In Vivo Response in a Murine Model of Infection
Journal article published in 2022 by
Dipti Sharma,
Raees A. Paul 
,
Shivaprakash M. Rudramurthy ,
Nisha Kashyap,
Sanjay Bhattacharya,
Rajeev Soman,
Shamanth A. Shankarnarayan,
Dipali Chavan,
Shreya Singh,
Parijit Das,
Harsimran Kaur,
Anup K. Ghosh ,
Rajendra Prasad,
Kaustuv Sanyal ,
Arunaloke Chakrabarti
,
Shivaprakash M. Rudramurthy ,
Nisha Kashyap,
Sanjay Bhattacharya,
Rajeev Soman,
Shamanth A. Shankarnarayan,
Dipali Chavan,
Shreya Singh,
Parijit Das,
Harsimran Kaur,
Anup K. Ghosh ,
Rajendra Prasad,
Kaustuv Sanyal ,
Arunaloke Chakrabarti
This paper is made freely available by the publisher.
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Abstract
Echinocandins are frontline antifungal agents in the management of invasive infections due to multidrug resistant Candida auris . The study aimed to evaluate echinocandin resistance in C. auris isolates of multicentric origin, identify the resistance mechanism, and analyze the pharmacodynamic response to caspofungin in a neutropenic mouse model of infection.