It is challenging to be a nurse because you have to deal with patients’ unstable states on the spot, especially during pandemics. There has been an escalation in the situation as a result of the spread of a novel Coronavirus, COVID-19, across the globe. The mental health and personal lives of nursing staff suffered as a result of overload and stress during this contagion. In this context, the current study aims to hinge on improving the family satisfaction and family life quality of frontline soldiers by mentoring quality through the mediating role of organization-based self-esteem. Against this backdrop, a sample of 450 nurse-family dyads was collected in a three-wave field survey to investigate the hypotheses concerning the subjects working in hospitals in Lahore, Pakistan. Data were analyzed through structural equation modeling using AMOS 26. The study results indicate that high mentoring quality positively impacts family satisfaction and family life quality. In light of the study findings, hospital administration has practical implications for improving the quality of mentoring in order to enhance the personal and professional lives of nurses.