AbstractAimTechnology including artificial intelligence (AI) may play a key role to strengthen primary health care services in resource‐poor settings. This systematic review aims to explore the evidence on the use of AI and digital health in improving primary health care service delivery.MethodsThree electronic databases were searched using a comprehensive search strategy without providing any restriction in June 2023. Retrieved articles were screened independently using the “Rayyan” software. Data extraction and quality assessment were conducted independently by two review authors. A narrative synthesis of the included interventions was conducted.ResultsA total of 4596 articles were screened, and finally, 48 articles were included from 21 different countries published between 2013 and 2021. The main focus of the included studies was noncommunicable diseases (n = 15), maternal and child health care (n = 11), primary care (n = 8), infectious diseases including tuberculosis, leprosy, and HIV (n = 7), and mental health (n = 6). Included studies considered interventions using AI, and digital health of which mobile‐phone‐based interventions were prominent. m‐health interventions were well adopted and easy to use and improved the record‐keeping, service deliver, and patient satisfaction.ConclusionAI and the application of digital technologies improve primary health care service delivery in resource‐poor settings in various ways. However, in most of the cases, the application of AI and digital health is implemented through m‐health. There is a great scope to conduct further research exploring the interventions on a large scale.