We describe two orthogonal radiography geometries at the OMEGA EP laser facility, which we refer to as side-on and face-on radiography. This setup can be used to determine quantitative information about the areal densities in solid, particulate, or liquid samples. We show sample images from these two different platforms that use the radiography diagnostic, one of material microjetting by the Richtmeyer–Meshkov instability and one of a deforming tin sample by the Rayleigh–Taylor instability, demonstrating the versatile applicability of such measurements in the field of high-energy density physics. The analytical methodology behind the quantitative Rayleigh–Taylor face-on radiography is also demonstrated and can be applied to other types of samples.