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Nature Research, Nature Biotechnology, 2023

DOI: 10.1038/s41587-023-01937-y

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Spatial multimodal analysis of transcriptomes and metabolomes in tissues

Journal article published in 2023 by Marco Vicari ORCID, Reza Mirzazadeh, Anna Nilsson, Reza Shariatgorji, Patrik Bjärterot ORCID, Ludvig Larsson, Hower Lee ORCID, Mats Nilsson ORCID, Julia Foyer, Markus Ekvall, Paulo Czarnewski, Xiaoqun Zhang, Per Svenningsson, Lukas Käll ORCID, Per E. Andrén ORCID and other authors.
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

AbstractWe present a spatial omics approach that combines histology, mass spectrometry imaging and spatial transcriptomics to facilitate precise measurements of mRNA transcripts and low-molecular-weight metabolites across tissue regions. The workflow is compatible with commercially available Visium glass slides. We demonstrate the potential of our method using mouse and human brain samples in the context of dopamine and Parkinson’s disease.