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Hindawi, Oxidative Medicine and Cellular Longevity, (2021), p. 1-15, 2021

DOI: 10.1155/2021/4793517

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Treatment of Radiation-Induced Brain Necrosis

Journal article published in 2021 by Xiaojing Yang ORCID, Hanru Ren ORCID, Jie Fu ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Radiation-induced brain necrosis (RBN) is a serious complication of intracranial as well as skull base tumors after radiotherapy. In the past, due to the lack of effective treatment, radiation brain necrosis was considered to be progressive and irreversible. With better understanding in histopathology and neuroimaging, the occurrence and development of RBN have been gradually clarified, and new treatment methods are constantly emerging. In recent years, some scholars have tried to treat RBN with bevacizumab, nerve growth factor, and gangliosides and have achieved similar results. Some cases of brain necrosis can be repairable and reversible. We aimed to summarize the incidence, pathogenesis, and treatment of RBN.