Published in

American Association for Cancer Research, Cancer Discovery, 3(11), p. 537-539, 2021

DOI: 10.1158/2159-8290.cd-21-0091

Links

Tools

Export citation

Search in Google Scholar

At the Heart of Immune Checkpoint Inhibitor–Induced Immune Toxicity

Journal article published in 2021 by Arabella Young ORCID, Jeffrey A. Bluestone
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

Full text: Unavailable

Green circle
Preprint: archiving allowed
Upload
Orange circle
Postprint: archiving restricted
Upload
Red circle
Published version: archiving forbidden
Policy details
Data provided by SHERPA/RoMEO

Abstract

AbstractSummary:Wei and colleagues showcase a genetic mouse model of immune-mediated myocarditis that shares homology with immune checkpoint inhibitor (CPI)–induced myocarditis in patients with cancer. They demonstrate that abatacept (CTLA4–Ig) limits cardiac toxicity in the mouse model and, thus, may ameliorate the CPI-induced myocarditis in patients with cancer while potentially maintaining antitumor activity.See related article by Wei et al., p. 614.