Abstract Very-high-energy (VHE; 100 GeV < E ≤ 100 TeV) and high-energy (HE; 100 MeV < E ≤ 100 GeV) gamma rays were observed from the symbiotic recurrent nova RS Ophiuchi (RS Oph) during its outburst in 2021 August by various observatories, such as the High Energy Stereoscopic System (HESS), Major Atmospheric Gamma Imaging Cherenkov (MAGIC), and Fermi-Large Area Telescope (LAT). The models that have been explored so far tend to favor a hadronic scenario of particle acceleration over an alternative leptonic scenario. This paper explores a time-dependent lepto-hadronic scenario to explain the emission from the RS Oph source region. We have used simultaneous low-frequency radio data observed by various observatories along with the data provided by HESS, MAGIC, and Fermi-LAT to explain the multiwavelength spectral energy distributions corresponding to 4 days after the outburst. Our results show that a lepto-hadronic interpretation of the source not only explains the observed HE-VHE gamma-ray data but the corresponding model synchrotron component is also consistent with the first 4 days of low-radio-frequency data, indicating the presence of nonthermal radio emission at the initial stage of the nova outburst. We have also calculated the expected neutrino flux from the source region and discuss the possibility of detecting neutrinos.