This study investigated the combined effects of competition area (4 × 4, 6 × 6, and 8 × 8 m) and judo-specific training type (tachi-waza, ne-waza, and free randori) on physiological responses and perceived exertion in female judo athletes. In a within-subject design, 12 female subelite and elite athletes who competed at regional or national levels with a mean training background of 8.4 ± 0.5 years performed the experimental conditions (i.e., combats (viz., matches) featuring different area/training type combinations) in random order. The following measurements at different time points were chosen: blood lactate before and after each match; heart rate before, mean, and peak for each match; and rating of perceived exertion immediately after each match. Two-factor analysis of variance was used to compare between conditions, while Bonferroni post hoc test and magnitude of difference were used to measure significance. There was no main effect of training type or area size on lactate before each match, heart rate (HR) before each match, HR mean during each match, and rating of perceived exertion. Main effects of training type and area size were found for lactate after each event, with the values being greater in free randori compared to tachi-waza and ne-waza and in 4 × 4 m compared to 6 × 6 and 8 × 8 m area. Main effects of training type and area size were also found in peak heart rate, with lower values in ne-waza compared to free randori and tachi-waza and in 8 × 8 m compared to 4 × 4 m area. The results demonstrate that varying training modality and area size may alter physiological responses during female judo combats by putting stress on the cardiovascular system and increasing anaerobic glycolysis solicitation.