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Nature Research, Nature Biotechnology, 2023

DOI: 10.1038/s41587-023-01825-5

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High-throughput measurement of the content and properties of nano-sized bioparticles with single-particle profiler

Journal article published in 2023 by Taras Sych, Jan Schlegel, Hanna M. G. Barriga, Miina Ojansivu, Leo Hanke ORCID, Florian Weber ORCID, R. Beklem Bostancioglu ORCID, Kariem Ezzat, Herbert Stangl, Birgit Plochberger ORCID, Jurga Laurencikiene, Samir El Andaloussi ORCID, Daniel Fürth, Molly M. Stevens ORCID, Erdinc Sezgin ORCID
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

AbstractWe introduce a method, single-particle profiler, that provides single-particle information on the content and biophysical properties of thousands of particles in the size range 5–200 nm. We use our single-particle profiler to measure the messenger RNA encapsulation efficiency of lipid nanoparticles, the viral binding efficiencies of different nanobodies, and the biophysical heterogeneity of liposomes, lipoproteins, exosomes and viruses.