Published in

Nature Research, Nature Biotechnology, 2023

DOI: 10.1038/s41587-023-01676-0

Links

Tools

Export citation

Search in Google Scholar

High-plex protein and whole transcriptome co-mapping at cellular resolution with spatial CITE-seq

Journal article published in 2023 by Yang Liu ORCID, Marcello DiStasio ORCID, Graham Su, Hiromitsu Asashima, Archibald Enninful, Xiaoyu Qin, Yanxiang Deng ORCID, Jungmin Nam ORCID, Fu Gao, Pino Bordignon ORCID, Marco Cassano, Mary Tomayko, Mina Xu ORCID, Stephanie Halene ORCID, Joseph E. Craft ORCID and other authors.
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

Full text: Unavailable

Green circle
Preprint: archiving allowed
Upload
Orange circle
Postprint: archiving restricted
Upload
Red circle
Published version: archiving forbidden
Policy details
Data provided by SHERPA/RoMEO

Abstract

AbstractIn this study, we extended co-indexing of transcriptomes and epitopes (CITE) to the spatial dimension and demonstrated high-plex protein and whole transcriptome co-mapping. We profiled 189 proteins and whole transcriptome in multiple mouse tissue types with spatial CITE sequencing and then further applied the method to measure 273 proteins and transcriptome in human tissues, revealing spatially distinct germinal center reactions in tonsil and early immune activation in skin at the Coronavirus Disease 2019 mRNA vaccine injection site.