Published in
American Association for the Advancement of Science, Science Translational Medicine, 599(13), 2021
DOI: 10.1126/scitranslmed.aba9772
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Reactivation of the tumor suppressor PTEN by mRNA nanoparticles enhances antitumor immunity in preclinical models
Journal article published in 2021 by
Yao-Xin Lin 
,
Yi Wang ,
Jianxun Ding ,
Aiping Jiang,
Jie Wang,
Mian Yu ,
Sara Blake ,
Shuaishuai Liu,
Charles J. Bieberich ,
Omid C. Farokhzad ,
Lin Mei ,
Hao Wang ,
Jinjun Shi
,
Yi Wang ,
Jianxun Ding ,
Aiping Jiang,
Jie Wang,
Mian Yu ,
Sara Blake ,
Shuaishuai Liu,
Charles J. Bieberich ,
Omid C. Farokhzad ,
Lin Mei ,
Hao Wang ,
Jinjun Shi
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Abstract
The restoration of tumor suppressor PTEN by synthetic mRNA nanoparticles sensitizes Pten -null or mutated tumors to immune checkpoint blockade therapy.