Published in
American Association for the Advancement of Science, Science, 6636(379), 2023
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Response to Comment on “Human TKTL1 implies greater neurogenesis in frontal neocortex of modern humans than Neanderthals”
Journal article published in 2023 by
Anneline Pinson 
,
Tomislav Maricic ,
Hugo Zeberg ,
Svante Pääbo ,
Wieland B. Huttner
,
Tomislav Maricic ,
Hugo Zeberg ,
Svante Pääbo ,
Wieland B. Huttner
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Abstract
Heraiet al. discuss the known fact that a low percentage of modern humans who lack any overt phenotypes carry the ancestralTKTL1allele. Our paper demonstrates that the amino acid substitution in TKTL1 increases neural progenitor cells and neurogenesis in the developing brain. It is another question if, and to what extent, this has consequences for the adult brain.