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Oxford University Press, Nucleic Acids Research, Web Server(32), p. W327-W331, 2004

DOI: 10.1093/nar/gkh454

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CD-Search: protein domain annotations on the fly

Journal article published in 2004 by Aron Marchler-Bauer ORCID, Stephen H. Bryant
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

We describe the Conserved Domain Search service (CD-Search), a web-based tool for the detection of structural and functional domains in protein sequences. CD-Search uses BLAST® heuristics to provide a fast, interactive service, and searches a comprehensive collection of domain models. Search results are displayed as domain architecture cartoons and pairwise alignments between the query and domain-model consensus sequences. Search results may be visualized in further detail by embedding the query sequence into multiple alignment displays and by mapping onto three-dimensional molecular graphic displays of known structures within the domain family. CD-Search can be accessed at http://www.ncbi.nlm.nih.gov/Structure/cdd/wrpsb.cgi.