Published in
American Society for Microbiology, mSystems, 1(6), 2021
DOI: 10.1128/msystems.00985-20
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Impaired Intestinal Akkermansia muciniphila and Aryl Hydrocarbon Receptor Ligands Contribute to Nonalcoholic Fatty Liver Disease in Mice
Journal article published in 2021 by
Zunji Shi,
Hehua Lei,
Gui Chen,
Peihong Yuan,
Zheng Cao 
,
Hooi-Leng Ser,
Xuehang Zhu,
Fang Wu,
Caixiang Liu,
Manyuan Dong,
Yuchen Song,
Yangyang Guo,
Chuan Chen,
Kexin Hu,
Yifan Zhu
and other authors.
,
Hooi-Leng Ser,
Xuehang Zhu,
Fang Wu,
Caixiang Liu,
Manyuan Dong,
Yuchen Song,
Yangyang Guo,
Chuan Chen,
Kexin Hu,
Yifan Zhu
and other authors.
This paper is made freely available by the publisher.
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Abstract
Our findings indicate that the gut-liver signaling axis contributes to saccharin/sucralose consumption-induced NAFLD. Supplementation with metformin or fructo-oligosaccharide is a potential therapeutic strategy for NAFLD treatment. In addition, we also developed a new nutritional strategy by using a natural sweetener (neohesperidin dihydrochalcone [NHDC]) as a substitute for NAS and free sugars.