Published in
Royal Society of Chemistry, RSC Chemical Biology, 2023
DOI: 10.1039/d2cb00247g
Links
Tools
A monoadduct generating Ru(ii) complex induces ribosome biogenesis stress and is a molecular mimic of phenanthriplatin
Journal article published in 2023 by
Richard J. Mitchell,
Sarah M. Kriger,
Alexander D. Fenton,
Dmytro Havrylyuk,
Ankit Pandeya,
Yang Sun 
,
Tami Smith,
Jason E. DeRouchey ,
Jason M. Unrine ,
Viral Oza,
Jessica S. Blackburn,
Yinan Wei ,
David K. Heidary ,
Edith C. Glazer
,
Tami Smith,
Jason E. DeRouchey ,
Jason M. Unrine ,
Viral Oza,
Jessica S. Blackburn,
Yinan Wei ,
David K. Heidary ,
Edith C. Glazer
This paper is made freely available by the publisher.
Full text: Download
Preprint: archiving forbidden
Data provided by 
Abstract
Phenanthriplatin forms DNA mono-adducts and induces ribosome biogenesis stress. Using a semi-rational strategy, Ru(ii) complexes were created that act as biological mimics of phenanthriplatin with improved properties.