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National Academy of Sciences, Proceedings of the National Academy of Sciences, 35(118), 2021

DOI: 10.1073/pnas.2107026118

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NMDA receptor–BK channel coupling regulates synaptic plasticity in the barrel cortex

Journal article published in 2021 by Ricardo Gómez ORCID, Laura E. Maglio ORCID, Alberto J. Gonzalez-Hernandez ORCID, Belinda Rivero-Pérez, David Bartolomé-Martín, Teresa Giraldez ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Significance N -methyl-D-aspartate (NMDA) receptors are critical triggers for neuronal plasticity. We show that large-conductance Ca 2+ - and voltage-gated K + (BK) channels serve as feedback regulators of NMDA receptor–mediated calcium influx to shape NMDA receptor–mediated synaptic potentials and consequently elevate the threshold for triggering plasticity at a subset of synapses.