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Oxford University Press, Nucleic Acids Research, Web Server(32), p. W37-W40, 2004

DOI: 10.1093/nar/gkh382

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3DCoffee@igs: a web server for combining sequences and structures into a multiple sequence alignment

Journal article published in 2004 by Olivier Poirot, Chantal Abergel, Karsten Suhre ORCID, Eamonn O'Toole, Cedric Notredame
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

This paper presents 3DCoffee@igs, a web-based tool dedicated to the computation of high-quality multiple sequence alignments (MSAs). 3D-Coffee makes it possible to mix protein sequences and structures in order to increase the accuracy of the alignments. Structures can be either provided as PDB identifiers or directly uploaded into the server. Given a set of sequences and structures, pairs of structures are aligned with SAP while sequence–structure pairs are aligned with Fugue. The resulting collection of pairwise alignments is then combined into an MSA with the T-Coffee algorithm. The server and its documentation are available from http://igs-server.cnrs-mrs.fr/Tcoffee/.