The literature on internal social responsibility, in which the work-family interface can be included, already has a robust tradition in scientific research. It is, therefore, important to systematize the path that has been taken and what the future may hold. This article aims to systematize the literature that simultaneously focuses on the work-family relationship and on the context of social responsibility and sustainability, with the purpose of mapping the research that has been produced on these intersections. A systematic review of the literature was conducted between the period 1968 and 2021. The search was performed on the SCOPUS database, and the analysis was conducted using the VOSviewer software, with 333 articles having been identified and subjected to a bibliometric and content analysis. As a result, 88 articles were analyzed in depth, focusing on the Work and Life Space dimension and the work-family relationship. The results indicate that corporate social responsibility has a positive effect on the work-family relationship, where an efficient balance between personal and professional life is often measured based on the adequacy of the adjustment of factors such as working hours and social and family commitments.