Background: Metabolic syndrome (MS) is associated with greater risk of morbimortality and it has high prevalence in people with mental illness. Objective: Estimate the prevalence of Metabolic Syndrome (MS) and its associated factors in the patients of a Psychosocial Care Center (CAPS in Brazilian Portuguese) in the city of Salvador, state of Bahia, Brazil. Method: Cross-sectional study set at CAPS in the city of Salvador-Bahia between August 2019 and February 2020. MS was evaluated according to the National Cholesterol Education Program’s Adult Treatment Panel III. In addition to descriptive statistics, gross and adjusted prevalence ratios were described. Results: MS was found in 100 (35.2%) individuals, 116 (40.9%) were obese and 165 (58.1%) had increased waist circumference. Polypharmacy was identified in 63 (22.3%) patients and 243 (85.9%) used antipsychotics. Under gross evaluation, women (PR = 1.88; 95%CI: 1.35–2.63) and those who used antidepressants (PR = 1.41; 95%CI: 1.05–1.88) showed an association with MS. After logistic regression, depression (PR = 1.86; 95%CI: 1.38–2.51), acanthosis (PR = 1.50; 95%CI: 1.18–1.90), use of antipsychotics (PR = 1.88; 95%CI: 1.13–2.75), and hypertriglyceridemic waist (PR = 3.33; 95%CI: 2.48–4.46) were associated with MS. Conclusion: The prevalence of MS signals multimorbidity among individuals with mental disorders and suggests a need for clinical screening.