Disruption of Active Trans-Sialidase Genes Impairs Egress from Mammalian Host Cells and Generates Highly Attenuated Trypanosoma cruzi Parasites
Journal article published in 2022 by
Gabriela de A. Burle-Caldas,
Nailma S. A. dos Santos,
Júlia T. de Castro,
Fernanda L. B. Mugge,
Viviane Grazielle-Silva,
Antônio Edson R. Oliveira,
Milton C. A. Pereira,
João Luís Reis-Cunha,
Anderson Coqueiro dos Santos,
Dawidson Assis Gomes,
Daniella C. Bartholomeu,
Nilmar S. Moretti 
,
Sergio Schenkman,
Ricardo T. Gazzinelli,
Santuza M. R. Teixeira
,
Sergio Schenkman,
Ricardo T. Gazzinelli,
Santuza M. R. Teixeira
This paper is made freely available by the publisher.
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Abstract
Trypanosoma cruziis the causative agent of Chagas disease, a neglected tropical disease that affects approximately 6 to 8 million people and for which there is no effective treatment or vaccine. The parasite expresses a family of surface proteins, named trans-sialidases, responsible for transferring sialic acid from host glycoconjugates to parasite mucins.