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American Physiological Society, American Journal of Physiology - Gastrointestinal and Liver Physiology, 5(323), p. G501-G510, 2022

DOI: 10.1152/ajpgi.00212.2022

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Myosin 5b is required for proper localization of the intermicrovillar adhesion complex in the intestinal brush border

Journal article published in 2022 by Sarah A. Dooley, Kristen A. Engevik ORCID, Jessica Digrazia, Rachel Stubler, Izumi Kaji ORCID, Evan Krystofiak, Amy C. Engevik
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

The intestinal epithelium absorbs nutrients and water through an elaborate apical membrane of highly organized microvilli. Microvilli organization is regulated by the intermicrovillar adhesion complexes, which create links between neighboring microvilli and control microvilli packing and density. In this study, we report a new trafficking partner of the IMAC, Myosin 5b. Loss of Myosin 5b results in a disorganized brush border and failure of IMAC proteins to reach the distal tips of microvilli.