Published in
American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 7(66), 2022
DOI: 10.1128/aac.00322-22
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Variants in Bedaquiline-Candidate-Resistance Genes: Prevalence in Bedaquiline-Naive Patients, Effect on MIC, and Association with Mycobacterium tuberculosis Lineage
Journal article published in 2022 by
Emmanuel Rivière 
,
Lennert Verboven ,
Anzaan Dippenaar ,
Sander Goossens ,
Elise De Vos,
Elizabeth Streicher ,
Bart Cuypers ,
Kris Laukens,
Fathia Ben-Rached,
Timothy C. Rodwell,
Arnab Pain,
Robin M. Warren,
Tim H. Heupink,
Annelies Van Rie
,
Lennert Verboven ,
Anzaan Dippenaar ,
Sander Goossens ,
Elise De Vos,
Elizabeth Streicher ,
Bart Cuypers ,
Kris Laukens,
Fathia Ben-Rached,
Timothy C. Rodwell,
Arnab Pain,
Robin M. Warren,
Tim H. Heupink,
Annelies Van Rie
This paper is made freely available by the publisher.
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Abstract
Studies have shown that variants in bedaquiline-resistance genes can occur in isolates from bedaquiline-naive patients. We assessed the prevalence of variants in all bedaquiline-candidate-resistance genes in bedaquiline-naive patients, investigated the association between these variants and lineage, and the effect on phenotype.