Acyl-coenzyme A binding protein (ACBP), also called diazepam-binding inhibitor (DBI) is a phylogenetically ancient protein that participates in paracrine and neuroendocrine signaling. Intriguingly, knockout of ACBP/DBI orthologues in yeast or nematodes increases lifespan, suggesting that the protein may have pro-aging effects, a conjecture that has not yet been investigated in vertebrates. Of note, in mice and human cells, ACBP/DBI inhibits autophagy, which is a well-studied antiaging mechanism. We previously showed that ACBP/DBI correlates with BMI, but also with age, and that these two correlations were independent. In this study, we plan to investigate the role of ACBP/DBI on age-related diseases such as cancer and cardiovascular diseases in humans from the DESIR cohort, a longitudinal cohort that recruited 5212 outpatients from the Loire valley between 1994 and 2010 with longitudinal follow-up every 3 years.