Dissemin is shutting down on January 1st, 2025

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Frontiers Media, Frontiers in Oncology, (11), 2021

DOI: 10.3389/fonc.2021.663221

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Low miR-214-5p Expression Correlates With Aggressive Subtypes of Pediatric ALCL With Non-Common Histology

Journal article published in 2021 by Piero Di Battista ORCID, Federica Lovisa, Enrico Gaffo, Ilaria Gallingani, Carlotta C. Damanti, Anna Garbin, Lavinia Ferrone, Elisa Carraro, Marta Pillon, Luca Lo Nigro ORCID, Rossella Mura, Marco Pizzi, Vincenza Guzzardo, Angelo Paolo Dei Tos, Alessandra Biffi and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The unsatisfactory cure rate of relapsing ALK-positive Anaplastic Large-Cell Lymphoma (ALCL) of childhood calls for the identification of new prognostic markers. Here, the small RNA landscape of pediatric ALK-positive ALCL was defined by RNA sequencing. Overall, 121 miRNAs were significantly dysregulated in ALCL compared to non-neoplastic lymph nodes. The most up-regulated miRNA was miR-21-5p, whereas miR-19a-3p and miR-214-5p were reduced in ALCL. Characterization of miRNA expression in cases that relapsed after first line therapy disclosed a significant association between miR-214-5p down-regulation and aggressive non-common histology. Our results suggest that miR-214-5p level may help to refine the prognostic stratification of pediatric ALK-positive ALCL.