Published in
Royal Society of Chemistry, Chemical Science, 6(14), p. 1569-1574, 2023
DOI: 10.1039/d2sc05973h
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Coupling of α-bromoamides and unactivated alkenes to form γ-lactams through EDA and photocatalysis
Journal article published in 2023 by
Sean M. Treacy,
Daniel R. Vaz 
,
Syed Noman,
Cédric Tard ,
Tomislav Rovis
,
Syed Noman,
Cédric Tard ,
Tomislav Rovis
This paper is made freely available by the publisher.
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Abstract
γ-Lactams are privileged heterocycles on route to the synthesis of pharmaceuticals. Herein, we demonstrate the facile synthesis of variously substituted γ-lactams utilizing electron donor–acceptor (EDA) complexes of amines and α-Br-amides.