Published in
American Society for Microbiology, Infection and Immunity, 8(90), 2022
DOI: 10.1128/iai.00232-22
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Extracellular vesicle formation in Cryptococcus deuterogattii impacts fungal virulence and requires the NOP16 gene
Journal article published in 2022 by
Rafael F. Castelli,
Fill tP,
Alana Pereira,
Leandro Honorato 
,
Alessandro Valdez,
de Oliveira Hc,
Haroldo C. de Oliveira,
Jaqueline M. Bazioli,
Bazioli Jm,
Garcia Awa,
Ane W. A. Garcia,
Tabata D’Maiella Freitas Klimeck,
Flavia C. G. Reis,
Staats Cc,
Charley C. Staats
and other authors.
,
Alessandro Valdez,
de Oliveira Hc,
Haroldo C. de Oliveira,
Jaqueline M. Bazioli,
Bazioli Jm,
Garcia Awa,
Ane W. A. Garcia,
Tabata D’Maiella Freitas Klimeck,
Flavia C. G. Reis,
Staats Cc,
Charley C. Staats
and other authors.
This paper is made freely available by the publisher.
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Abstract
Small molecules are components of fungal extracellular vesicles (EVs), but their biological roles are only superficially known. NOP16 is a eukaryotic gene that is required for the activity of benzimidazoles against Cryptococcus deuterogattii . In this study, during the phenotypic characterization of C. deuterogattii mutants lacking NOP16 expression, we observed that this gene was required for EV production.