Abstract The growth of trees in riparian forests in semi-arid savannas is resilient to the natural variations in temperature and precipitation due to the availability of riverine water. Climate change can nevertheless, intensify the evapotranspiration of tree species, altering biodiversity, plant productivity and ecosystem services. Understanding the growth response of riparian tree species to climate change is, therefore, critical for their management and conservation. Here, we used 23 cross-dated stem discs of Anogeissus leiocarpus (DC.) Guill. and Perr. and Afzelia africana Sm. randomly sampled from riparian forests in the humid and dry savanna regions of Ghana to assess their growth response to climate change. A generalized additive mixed model (GAMM) was used to integrate species-specific basal area increments to an array of explanatory variables that may affect growth, including tree size and seasonal temperature and precipitation between 1982 and 2013. We observed significant association between tree size, rainy and dry season temperatures and precipitation variables, and changes in tree growth. Despite the strong fluctuations in tree growth over time, the estimated growth rates of the species from the residuals of the GAMMs showed no significant change in growth. Our findings suggest that these riparian forests are highly resistant to weather extremes and therefore, might persist (up to a certain point) even if climate change continues to intensify.