The changing climate and global warming have rendered existing surface water insufficient, which is projected to adversely influence the irrigated farming systems globally. Consequently, groundwater demand has increased significantly owing to increasing population and demand for plant-based foods especially in South Asia and Pakistan. This study aimed to determine the potential areas for groundwater use for agriculture sector development in the study area Lower Dir District. ArcGIS 10.4 was utilized for geospatial analysis, which is referred to as Multi Influencing Factor (MIF) methodology. Seven parameters including land cover, geology, soil, rainfall, underground faults (liniment) density, drainage density, and slope, were utilized for delineation purpose. Considering relative significance and influence of each parameter in the groundwater recharge rating and weightage was given and potential groundwater areas were classified into very high, high, good, and poor. The result of classification disclosed that the areas of 113.10, 659.38, 674.68, and 124.17 km2 had very high, high, good, and poor potential for groundwater agricultural uses, respectively. Field surveys for water table indicated groundwater potentiality, which was high for Kotkay and Lalqila union councils having shallow water table. However, groundwater potentiality was poor in Zimdara, Khal, and Talash, characterized with a very deep water table. Moreover, the study effectively revealed that remote sensing and GIS could be developed as potent tools for mapping potential sites for groundwater utilization. Furthermore, MIF technique could be a suitable approach for delineation of groundwater potential zone, which can be applied for further research in different areas.