Abstract Ultraluminous infrared galaxies (ULIRGs) have infrared luminosities L _IR ≥ 10¹² L _⊙, making them the most luminous objects in the infrared sky. These dusty objects are generally powered by starbursts with star formation rates that exceed 100 M _⊙ yr⁻¹, possibly combined with a contribution from an active galactic nucleus. Such environments make ULIRGs plausible sources of astrophysical high-energy neutrinos, which can be observed by the IceCube Neutrino Observatory at the South Pole. We present a stacking search for high-energy neutrinos from a representative sample of 75 ULIRGs with redshift z ≤ 0.13 using 7.5 yr of IceCube data. The results are consistent with a background-only observation, yielding upper limits on the neutrino flux from these 75 ULIRGs. For an unbroken E ^−2.5 power-law spectrum, we report an upper limit on the stacked flux Φ ν μ + ν ¯ μ 90 % = 3.24 × 10 − 14 TeV − 1 cm − 2 s − 1 ( E / 10 TeV ) − 2.5 at 90% confidence level. In addition, we constrain the contribution of the ULIRG source population to the observed diffuse astrophysical neutrino flux as well as model predictions.