Sustained Replication of Synthetic Canine Distemper Virus Defective Genomes In Vitro and In Vivo
Journal article published in 2021 by
Natasha L. Tilston-Lunel 
,
Stephen R. Welch ,
Sham Nambulli ,
Rory D. de Vries,
Gregory W. Ho,
David E. Wentworth,
Reed Shabman,
Stuart T. Nichol,
Christina F. Spiropoulou ,
Rik L. de Swart ,
Linda J. Rennick ,
W. Paul Duprex,
W. Paul Duprex ,
Benhur Lee
,
Stephen R. Welch ,
Sham Nambulli ,
Rory D. de Vries,
Gregory W. Ho,
David E. Wentworth,
Reed Shabman,
Stuart T. Nichol,
Christina F. Spiropoulou ,
Rik L. de Swart ,
Linda J. Rennick ,
W. Paul Duprex,
W. Paul Duprex ,
Benhur Lee
This paper is made freely available by the publisher.
Full text: Download
Data provided by 
Abstract
Defective interfering (DI) genomes have long been considered inconvenient artifacts that suppressed viral replication in vitro . However, advances in sequencing technologies have led to DI genomes being identified in clinical samples, implicating them in disease progression and outcome.