Published in
American Society for Microbiology, Microbiology Spectrum, 2(9), 2021
DOI: 10.1128/spectrum.00904-21
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Risk Factors for Being Seronegative following SARS-CoV-2 Infection in a Large Cohort of Health Care Workers in Denmark
,
Mikkel Gybel-Brask ,
Jonas Henrik Kristensen,
Rasmus Bo Hasselbalch,
Mia Marie Pries-Heje,
Pernille Brok Nielsen,
Andreas Dehlbæk Knudsen,
Kamille Fogh ,
Jakob Boesgaard Norsk,
Ove Andersen,
Claus Antonio Juul Jensen,
Christian Torp-Pedersen,
Jørgen Rungby,
Sisse Bolm Ditlev
and other authors.
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Abstract
Most individuals seroconvert after infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), but negative serology is observed in 1 to 9%. We found that asymptomatic or mild infection as well as a BMI above 30 were associated with being seronegative. Since the presence of antibodies against SARS-CoV-2 reduces the risk of reinfection, efforts to protect HCW with risk factors for being seronegative may be needed in future COVID-19 surges.