Published in
American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 10(66), 2022
DOI: 10.1128/aac.00817-22
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Susceptibilities of Ugandan Plasmodium falciparum Isolates to Proteasome Inhibitors
Journal article published in 2022 by
Shreeya Garg,
Oriana Kreutzfeld 
,
Sevil Chelebieva,
Patrick K. Tumwebaze,
Oswald Byaruhanga,
Martin Okitwi,
Stephen Orena,
Thomas Katairo,
Samuel L. Nsobya,
Melissa D. Conrad ,
Ozkan Aydemir,
Jennifer Legac,
Alexandra E. Gould,
Brett R. Bayles,
Jeffrey A. Bailey
and other authors.
,
Sevil Chelebieva,
Patrick K. Tumwebaze,
Oswald Byaruhanga,
Martin Okitwi,
Stephen Orena,
Thomas Katairo,
Samuel L. Nsobya,
Melissa D. Conrad ,
Ozkan Aydemir,
Jennifer Legac,
Alexandra E. Gould,
Brett R. Bayles,
Jeffrey A. Bailey
and other authors.
This paper is made freely available by the publisher.
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Abstract
The proteasome is a promising target for antimalarial chemotherapy. We assessed ex vivo susceptibilities of fresh Plasmodium falciparum isolates from eastern Uganda to seven proteasome inhibitors: two asparagine ethylenediamines, two macrocyclic peptides, and three peptide boronates; five had median IC 50 values <100 nM.