This study aimed to evaluate intake, digestibility, nitrogen balance, ingestive behavior, and blood parameters of sheep fed with cotton lint levels. Twenty rams weighing 30.2 ± 3.7 kg and aged 12 ± 1.3 months were distributed in a completely randomized design, with four treatments and five repetitions. Diets consisted of 50% roughage and 50% concentrate. The treatments consisted of replacing corn with cotton lint at levels of 0, 70, 140, and 210 g/kg of dry matter (DM) of the diets. The animals’ feeding behavior was determined in the last three days of the experimental period. Data were subjected to regression analysis. Decreased linear effect (p < 0.05) was observed for the nutritional fraction’s intake. However, neutral detergent fibre (NDF) intake and plasma urea-N were not affected (p > 0.05) by lint levels. Apparent digestibility of DM, crude protein (CP), ethereal extract (EE), and non-fibrous carbohydrate (NFC) were affected (p < 0.05), except for total carbohydrate. There was a decreased linear effect (p < 0.05) for the intake efficiency of DM and NDF in g/h. The nitrogen balance (g/day) and glucose levels (mg/dL) were reduced with the addition of lint in the diet. The addition of cotton lint up to 70 g/kg in DM can be used over a short-term period.