Vernier-effect has been widely employed in interferometer-based optical fiber sensors to improve the sensitivities greatly. However, the influence of the Vernier-effect on detection limit (DL) that is more important for evaluating the actual performance of the sensor has not been discussed. Two gas pressure fiber sensors (a typical Fabry-Perot interferometer-based sensor and a Vernier sensor) are used to compare the DL of them by experiments. Both the theoretical analysis and the experimental results show that, though the Vernier-effect magnifies the spectrum shift sensitivity, it also magnifies the value of the smallest detectable wavelength shift. As a result, the actual DL of the sensor is not improved by employing the Vernier-effect. If the contrast ratio of the Vernier envelope is not optimized enough for most of the reported sensors, the DL can even degenerate greatly.