Published in
American Physiological Society, American Journal of Physiology - Heart and Circulatory Physiology, 6(320), p. H2416-H2428, 2021
DOI: 10.1152/ajpheart.00914.2020
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Neuregulin-1 compensates for endothelial nitric oxide synthase deficiency
Journal article published in 2021 by
Hadis Shakeri,
Jente R. A. Boen 
,
Sofie De Moudt,
Jhana O. Hendrickx ,
Arthur J. A. Leloup,
Griet Jacobs ,
Guido R. Y. De Meyer ,
Gilles W. De Keulenaer,
Pieter-Jan D. F. Guns ,
Vincent F. M. Segers
,
Sofie De Moudt,
Jhana O. Hendrickx ,
Arthur J. A. Leloup,
Griet Jacobs ,
Guido R. Y. De Meyer ,
Gilles W. De Keulenaer,
Pieter-Jan D. F. Guns ,
Vincent F. M. Segers
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Abstract
ECs compensate for eNOS deficiency by increasing the secretion of NRG1. NRG1 administration prevents cardiac and renal hypertrophy and fibrosis caused by ANG II infusion and eNOS deficiency. NRG1 expression is regulated by miR-134.