American Physiological Society, American Journal of Physiology - Heart and Circulatory Physiology, 5(321), p. H905-H919, 2021
DOI: 10.1152/ajpheart.00254.2021
Full text: Unavailable
We showed that male amyloid precursor protein (APP) transgenic mice have higher circulating stress hormone levels. As a result, higher systolic blood pressure and pulse-wave velocity were measured in vivo in addition to a smaller α-adrenergic receptor-dependent contraction upon ex vivo stimulation with phenylephrine. Our findings highlight the need for more frequent assessment of circulating stress hormone levels and PWV measurements in daily clinical practice for people at risk of Alzheimer’s disease.