Published in

American Society for Microbiology, Microbiology Spectrum, 5(10), 2022

DOI: 10.1128/spectrum.00609-22

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Boosting with Multiple Doses of mRNA Vaccine after Priming with Two Doses of Protein Subunit Vaccine MVC-COV1901 Elicited Robust Humoral and Cellular Immune Responses against Emerging SARS-CoV-2 Variants

Journal article published in 2022 by Chun-Hsiang Chiu, Yu-Hsiu Chang, Chi-Wei Tao, Feng-Yee Chang, Kuo-Chou Chiu, Tien-Wei Chang, Li-Chen Yen ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Vaccination is the most important strategy to combat the COVID-19 outbreak; however, it remains to be determined whether heterologous prime-boost regimens could induce equal or even stronger immune responses against SARS-CoV-2. Here, we showed that boosting the additional doses of mRNA-1273 (Mod) priming with two doses of MVC-COV1901 (MVC) (2× MVC/Mod) improved humoral and cellular immunity compared to two doses of AZD1222 (2× AZ) or MVC (2× MVC) against SARS-CoV-2 variants.