Published in
American Society of Hematology, Blood Advances, 5(5), p. 1273-1277, 2021
DOI: 10.1182/bloodadvances.2020003125
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Disruption of CSF-1R signaling inhibits growth of AML with inv(16)
Journal article published in 2021 by
Alexander Simonis 
,
Nicole Wildner-Verhey van Wijk,
Norman F. Russkamp ,
Jan Mueller,
C. Matthias Wilk,
C. Matthias Wilk ,
Mattheus H. E. Wildschut ,
Renier Myburgh,
Nicole Wildner-Verhey van Wijk,
Rouven Mueller,
Stefan Balabanov,
Peter J. M. Valk,
Alexandre P. A. Theocharides,
Markus G. Manz
,
Nicole Wildner-Verhey van Wijk,
Norman F. Russkamp ,
Jan Mueller,
C. Matthias Wilk,
C. Matthias Wilk ,
Mattheus H. E. Wildschut ,
Renier Myburgh,
Nicole Wildner-Verhey van Wijk,
Rouven Mueller,
Stefan Balabanov,
Peter J. M. Valk,
Alexandre P. A. Theocharides,
Markus G. Manz
This paper is made freely available by the publisher.
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Abstract
Key Points Human inv(16) AML cells express CSF-1R and are exposed to CSF-1 in vivo. Inhibition of CSF-1R signaling reduces viability of inv(16) AML cells in vitro and in therapeutic settings in humanized mice in vivo.