Published in
American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 11(65), 2021
DOI: 10.1128/aac.01137-21
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Baloxavir Treatment Delays Influenza B Virus Transmission in Ferrets and Results in Limited Generation of Drug-Resistant Variants
Journal article published in 2021 by
Philippe Noriel Q. Pascua,
Jeremy C. Jones,
Bindumadhav M. Marathe,
Patrick Seiler,
William V. Caufield,
Burgess B. Freeman,
Richard J. Webby,
Elena A. Govorkova 
This paper is made freely available by the publisher.
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Abstract
Clinical efficacy of the influenza antiviral baloxavir marboxil (baloxavir) is compromised by treatment-emergent variants harboring a polymerase acidic protein I38T (isoleucine-38-threonine) substitution. However, the fitness of I38T-containing influenza B viruses (IBVs) remains inadequately defined.